![]() Early evidence suggests that intake of 2 g/day sarcosine as add-on therapy to many antipsychotics except clozapine. Sarcosine has been investigated in relation to schizophrenia. Surfactants Ī variety of surfactants are produced from sarcosine. The concentration of sarcosine in blood serum of normal human subjects is 1.4 ± 0.6 micromolar. Sarcosine is rapidly degraded to glycine, which, in addition to its importance as a constituent of protein, plays a significant role in various physiological processes as a prime metabolic source of components of living cells such as glutathione, creatine, purines and serine. Sarcosine, like the related compounds dimethylglycine (DMG) and trimethylglycine (TMG), is formed via the metabolism of nutrients such as choline and methionine, which both contain methyl groups used in a wide range of biochemical reactions. Sarcosine is an intermediate in the metabolism of choline to glycine. In the laboratory, it may be synthesized from chloroacetic acid and methylamine. Sarcosine is an amino acid derivative that is naturally found in muscles and other body tissues. Sarcosine is metabolized to glycine by the enzyme sarcosine dehydrogenase, while glycine- N-methyl transferase generates sarcosine from glycine. Sarcosine is an intermediate and byproduct in glycine synthesis and degradation. ![]()
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